C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/22 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2654019
The present application provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF. responsive disorders, for example, certain HGF responsive tumors.
La présente invention concerne une famille de protéines de liaison qui se lient au facteur de croissance des cellules hépatiques (HGF), en particulier le HGF humain, et en neutralisent l'activité. Les protéines de liaison peuvent être utilisées en tant qu'agents diagnostiques et/ou agents thérapeutiques. En ce qui concerne leur activité thérapeutique, les protéines de liaison peuvent être utilisées pour traiter certains troubles sensibles au HGF, par exemple, certaines tumeurs sensibles au HGF.
Breault Lyne
Etemad-Gilbertson Bijan
Gyuris Jeno
Han May
Knuehl Christine
Aveo Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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