Hepatocyte growth factor receptor antagonists and uses thereof

Details Hepatocyte growth factor receptor antagonists and uses thereof Hepatocyte growth factor receptor antagonists and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 1/22 (2006.01) C07K 14/71 (2006.01) C07K 14/76 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C10G 65/02 (2006.01) C10G 65/04 (2006.01) C10G 65/08 (2006.01) C12N 5/18 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223269

Hepatocyte growth factor (HGF) receptor antagonists are provided. The HGF receptor antagonists include HGF receptor antibodies and fragments thereof. The HGF receptor antagonists can be employed to block binding of HGF to HGF receptors or substantially inhibit HGF receptor activation. The HGF receptor antagonists may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treating cancer using the HGF receptor antagonists are also provided.

L'invention concerne des antagonistes du récepteur de croissance des hépatocytes (HGF), qui comportent des anticorps contre le récepteur HGF et des fragments de ceux-ci. Lesdits antagonistes du récepteur de HGF peuvent être utilisés pour bloquer la liaison du HGF aux récepteurs de HGF ou pour inhiber sensiblement l'activation du récepteur de HGF. Les antagonistes de HGF peuvent être intégrés dans des compositions pharmaceutiques, des articles manufacturés ou des trousses. L'invention porte également sur des méthodes de traitement du cancer au moyen desdits antagonistes du récepteur de HGF.

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