C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 35/12 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 14/71 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) C12N 15/62 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2624535
Novel polypeptides that are splice variants of c-Met, the receptor for hepatocyte growth factor and polynucleotides encoding same are provided. Methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin- related disorders using the polypeptides and polynucleotides of the present invention, are also provided.
Cette invention concerne des polypeptides qui sont des variants d'épissure de c-Met, récepteur du facteur de croissance des hépatocytes, et des polynucléotides codant pour ces polypeptides. Sont également décrites des méthodes et des compositions pouvant s'utiliser pour le traitement de diverses pathologies telles que le cancer ou de troubles à caractère immunologique, hématologique ou dermatologique au moyen des polypeptides et des polynucléotides de l'invention.
Ayalon-Soffer Michal
Beiman Merav
Hermesh Chen
Levine Zurit
Oren Anat
Compugen Ltd.
Ridout & Maybee Llp
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