Hepatocytes and chondrocytes from adherent placental stem...

A - Human Necessities – 01 – K

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A01K 67/027 (2006.01) A61F 2/30 (2006.01) A61K 35/50 (2006.01) A61L 27/38 (2006.01) A61P 1/16 (2006.01) A61P 19/00 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2677679

Provided herein are methods and compositions for the production of hepatocytes from placenta stem cells. Further provided herein is the use of such hepatocytes in the treatment of, and intervention in, for example, trauma, inflammation, and degenerative disorders of the liver. Also provided herein are compositions and methods relating to combinations of nanofibrous scaffolds and adherent placental stem cells and methods of using the same in cartilage repair. Finally, provided herein are compositions and methods relating to nonadherent, CD34+CD45- stem cells from placenta.

L'invention concerne des procédés et des compositions pour la production d'hépatocytes à partir de cellules souches du placenta. L'invention concerne en outre l'utilisation de ces hépatocytes dans l'action thérapeutique et l'intervention sur, par exemple, un traumatisme, une inflammation et des troubles dégénératifs du foie. L'invention concerne également des compositions et des procédés associés à des combinaisons d'échafaudages nanofibreux et de cellules souches placentaires adhérentes et des procédés d'utilisation de ceux-ci dans la réparation cartilagineuse. Enfin, l'invention concerne des compositions et des procédés associés aux cellules souches CD34+CD45- non adhérentes provenant du placenta.

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