Hepatoma treatment with somatostatin analogs

Details Hepatoma treatment with somatostatin analogs Hepatoma treatment with somatostatin analogs

A - Human Necessities

61

K

A61K 38/31 (2006.01) C07K 14/655 (2006.01)

Patent

CA 2107773

2107773 9316718 PCTABS00025 A method for treating liver cancer in a mammalian subject. The method includes administering to the subject a composition which contains a therapeutically effective amount of an octapeptide of the following formula: H-A1-Cys-A2-D-Trp-Lys-A3-Cys-A4-Y wherein, A1 is D-.beta.-Nal or D-Phe; A2 is Phe, pentafluro-Phe, or p-substituted X-Phe where X is a halogen, NH2, NO2, OH, or C1-3 alkyl; A3 is Thr, Ser, Phe, Val, .alpha.-aminobutyric acid, or Ile; A4 is Thr, $(b)-Nal, or Trp; and Y is NH2 or OH; or a pharmaceutically acceptable salt of complex thereof.

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