Hepatoprotectant acetaminophen mutual prodrugs

Details Hepatoprotectant acetaminophen mutual prodrugs Hepatoprotectant acetaminophen mutual prodrugs

C - Chemistry, Metallurgy

07

C

C07C 323/58 (2006.01) A61K 31/223 (2006.01) A61K 31/427 (2006.01) A61K 31/661 (2006.01) A61P 29/00 (2006.01) A61P 39/00 (2006.01) C07C 323/59 (2006.01) C07D 277/38 (2006.01) C07F 9/09 (2006.01) C07H 19/167 (2006.01) C07K 5/023 (2006.01)

Patent

CA 2724788

The present invention provides hepatoprotectant acetaminophen mutual prodrugs, which have an acetaminophen moiety covalently linked to a second moiety that may act as a hepatoprotectant against acetaminophen hepatotoxicity. Additionally, acetaminophen mutual prodrugs may have improved water solubility which may provide better suitability for parenteral and other dosage forms relative to administration of acetaminophen. Also provided are methods of treating a disease or condition that is responsive to acetaminophen (such as fever, pain and ischemic injury) using hepatoprotectant acetaminophen mutual prodrugs, as well as kits and unit dosages.

L'invention porte sur des promédicaments mutuels d'acétaminophène et d'hépatoprotecteur comprenant une fraction d'acétaminophène liée par covalence à une deuxième fraction pouvant agir comme hépatoprotecteur contre l'hépatotoxicité de l'acétaminophène. Ces promédicaments peuvent présenter une solubilité dans l'eau améliorée se prêtant mieux à l'administration parentérale de l'acétaminophène ou sous d'autres formes posologiques. L'invention porte également sur des méthodes de traitement de maladies ou d'états sensibles à l'acétaminophène (tels que fièvre, douleur ou lésion ischémique) utilisant lesdits promédicaments, ainsi que sur des trousses et des doses unitaires.

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