Hepatospecific insulin analogues

Details Hepatospecific insulin analogues Hepatospecific insulin analogues

C - Chemistry, Metallurgy

07

K

530/7.4

C07K 14/62 (2006.01) A61K 38/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2014896

Hepatospecific Insulin Analogues Abstract New insulin analogues have now been synthesized and found to be hepatospecific. These insulin analogues contain substitutions for one or more amino acids in the A and B chains. Specifically, tryptophan or other bulky, hydrophobic residues are substituted at the A13, A14, A15, A19 and B16 positions of the insulin polypeptide to produce the hepatospecific insulin analogues of the claimed invention.

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