Hepatotoxicity molecular models

Details Hepatotoxicity molecular models Hepatotoxicity molecular models

G - Physics

01

N

G01N 33/52 (2006.01)

Patent

CA 2562343

The present invention includes methods of predicting hepatotoxicity of test agents and methods of generating hepatotoxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes microarrays, computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users for determining the toxicity of test agents.

L'invention concerne des procédés de prévision de l'hépatotoxicité d'agents d'essai et des procédés d'établissement de modèles de prévision d'hépatotoxicité qui font appel à des algorithmes d'analyse d'information d'expression génique quantitative. L'invention concerne également des microréseaux, des systèmes informatiques incorporant les modèles de prévision de toxicité, et des procédés d'utilisation des systèmes informatiques par des utilisateurs distants pour la détermination de la toxicité d'agents d'essai.

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