A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2141028
By carrying out the conjugation of the antiviral drugs such as ara-AMP, acyclovir and the like with a carrier selected among basic polyaminoacids and, particularly, with poly-L-lysine or poly- L-ornythine wherein the major part of the amino groups, which are not substituted by antiviral drugs, are substituted by galactose molecules, the intramuscular administration of the drug without antibodies formation, without acute toxicity and with a hepatic targeting, is made possible.
Il est possible d'administrer par voie intramusculaire, sans formation d'anticorps ni toxicité aiguë, et selon un ciblage hépatique, des médicaments antiviraux tels que le monophosphate d'adénine d'arabinoside (ara-AMP), l'acyclovir et autres, par la conjugaison de ces médicaments avec un véhicule choisi parmi des polyaminoacides basiques et, en particulier, avec poly-L-lysine ou poly-L-ornythine, la majeure partie des groupes amino qui ne sont pas substitués par les médicaments antiviraux étant substituée par des molécules de galactose.
Baldacci Massimo
Busi Corrado
Di Stefano Giuseppina
Fiume Luigi
Mattioli Alessandro
Laboratori Baldacci S.p.a.
Marks & Clerk
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