Hepoxilin analog enantiomers

Details Hepoxilin analog enantiomers Hepoxilin analog enantiomers

C - Chemistry, Metallurgy

07

C

C07C 69/732 (2006.01) A61K 31/215 (2006.01) A61K 31/336 (2006.01) A61P 35/00 (2006.01) C07C 67/48 (2006.01) C07C 303/38 (2006.01)

Patent

CA 2643972

The present invention relates to enantiomeric forms of hepoxilin analogs of Formula I-VIII, pharmaceutical compositions thereof, a method for the separation of said enantiomeric forms of hepoxilin analogs comprising applying said hepoxilin to a chiral phase HPLC column and eluting said hepoxilin with an alkane and alcohol solvent mixture. Said enantiomeric forms of hepoxilin analogs of Formula I-VIII were found to be useful in controlling the biological effects of PPAR mediated transcriptional control for the treatment of diseases such as cancer, thromboxane-mediated diseases and for modulating intracellular calcium concentration.

La présente invention concerne des formes énantiomères d'analogues de l'hépoxiline des formules I à VIII, leurs compositions pharmaceutiques et un procédé de séparation des formes énantiomères des analogues de l'hépoxiline consistant à appliquer l'hépoxiline à une colonne HPLC en phase chirale et éluer l'hépoxiline avec un alcane et un mélange de solvant alcoolique. Ces formes énantiomères des analogues de l'hépoxiline des formules I à VIII s'avèrent être utiles pour contrôler les effets biologiques de la régulation trancriptionnelle induite par PPAR dans le traitement de maladies telles que le cancer, des maladies induites par le thromboxane et dans la modulation de la concentration intracellulaire du calcium.

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