Her-2/neu fusion proteins

Details Her-2/neu fusion proteins Her-2/neu fusion proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/71 (2006.01) C12N 5/02 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 35/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2361009

The present invention is generally directed to HER-2/neu fusion proteins, nucleic acid molecules encoding HER-2/neu fusion proteins, viral vectors expressing HER-2/neu fusion proteins, and pharmaceutical compositions (e.g.vaccines) comprising the HER-2/neu fusion proteins and/or nucleic acid molecules encoding the HER-2/neu fusion proteins. The present invention is also directed to methods of treating or preventing cancer by eliciting or enhancing an immune response to the HER-2/neu protein, including for uses in the treatment of malignancies associated with the HER-2/neu oncogene.

La présente invention concerne de façon générale les protéines de fusion HER-2/neu, les molécules d'acide nucléique codant les protéines de fusion HER-2/neu, des vecteurs viraux exprimant les protéines de fusion HER-2/neu, et des compositions pharmaceutiques (par exemples, des vaccins) contenant les protéines de fusion HER-2/neu et/ou les molécules d'acide nucléique codant ces protéines de fusion HER-2/neu. En outre, cette invention concerne des méthodes de traitement ou de prévention du cancer, consistant à provoquer ou à renforcer la réponse immunitaire à la protéine HER-2/neu, y compris dans les utilisations destinées au traitement des cancers associés à l'oncogène du HER-2/neu.

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