C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/725 (2006.01) C07K 14/82 (2006.01) C12N 15/86 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2417915
The present invention is generally directed to Her-2/neu fusion proteins, nucleic acid molecules encoding Her-2/neu fusion proteins, viral vectors expressing Her-2/neu fusion proteins, and pharmaceutical compositions (e.g., vaccines) comprising the Her-2/neu fusion proteins and/or nucleic acid molecules encoding the Her-2/neu fusion proteins. The present invention is also directed to methods of treating or preventing cancer by eliciting or enhancing an immune response to the Her-2/neu protein, including for uses in the treatment of malignancies associated with the Her-2/neu oncogene.
L'invention concerne de nouvelles protéines de fusion Her-2/neu, des molécules d'acide nucléique codant pour ces protéines, des vecteurs viraux exprimant ces protéines et des compositions pharmaceutiques (p. ex. des vaccins) renfermant lesdites protéines et/ou les molécules d'acide nucléique codant pour lesdites protéines. L'invention concerne également des méthodes de traitement ou de prévention du cancer par le déclenchement ou l'amélioration d'une réponse immunitaire à la protéine Her-2/neu, dont le traitement de tumeurs malignes associées à l'oncogène Her-2/neu.
Cheever Martin A.
Gheysen Dirk
Corixa Corporation
Fetherstonhaugh & Co.
Smithkline Beecham Biologicals S.a.
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