Her2 antibody composition

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/32 (2006.01)

Patent

CA 2574821

A composition comprising a main species HER2 antibody that binds to domain II of HER2, and an amino acid sequence variant thereof comprising an amino- terminal leader extension is disclosed. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition are also disclosed.

La présente invention concerne une composition comprenant une espèce principale d'anticorps anti-HER2 qui se lie au domaine II de HER2, ainsi qu'une variante de séquence d'acides aminés de celle-ci, comprenant une extension de tête amino-terminale. Cette invention concerne aussi des préparations pharmaceutiques comprenant ladite composition, ainsi que des utilisations thérapeutiques de cette composition.

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