Her2/neu-specific antibodies and methods of using same

Details Her2/neu-specific antibodies and methods of using same Her2/neu-specific antibodies and methods of using same

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2720368

This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as compared to known 4D5 antibodies. The invention also relates to methods of using the 4D5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.

La présente invention concerne des anticorps qui se lient spécifiquement à HER2/neu, et particulièrement des anticorps 4D5 chimères contre HER2/neu, qui ont une glycosylation réduite par rapport à des anticorps 4D5 connus. Linvention concerne en outre des procédés dutilisation des anticorps 4D5 et des compositions comprenant ceux-ci dans le diagnostic, le pronostic et la thérapie de maladies telles que le cancer, des maladies auto-immunes, des troubles inflammatoires, et des maladies infectieuses.

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