C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/1.23
C12N 15/54 (2006.01) C07K 14/71 (2006.01) C12N 9/12 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2037440
ABSTRACT The cloning, sequence and expression of a novel member of the EGFR/neu subfamily of receptor tyrosine kinases, termed HER3, is described. The HER3 precursor comprises 1342 amino acid residues, 1323 residues of which comprise the mature HER3. Recombinant HER3 does not interact with the homologous ligands EGF and TGF-.alpha.. A 160 kD phosphoprotein is present in cells expressing both HER3 and membrane-associated Amphiregulin, whereas the 170 kD EGF receptor is completely absent. Immunoprecipitation experiments suggest this 160 kD phosphoprotein is HER3 and that it is present only when coexpressed with the integral membrane form of the AR precursor.
Plowman Gregory D.
Shoyab Mohammed
Whitney Gena S.
Barrigar & Moss
Bristol-Myers Squibb Company
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