Her4 human receptor tyrosine kinase

Details Her4 human receptor tyrosine kinase Her4 human receptor tyrosine kinase

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 14/475 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2103323

ABSTRACT The molecular cloning, expression, and biological characteristics of a novel receptor tyrosine kinase related to the epidermal growth factor receptor, termed HER4/p180erbB4, are described. A HER4 ligand capable of inducing cellular differentiation of breast cancer cells is also disclosed. In view of the expression of HER4 in several human cancers and in certain tissues of neuronal and muscular origin, various diagnostic and therapeutic uses of HER4-derived and HER4-related biological compositions are provided.

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