Her4 human receptor tyrosine kinase

Details Her4 human receptor tyrosine kinase Her4 human receptor tyrosine kinase

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) C07K 4/12 (2006.01) C07K 14/31 (2006.01) C07K 14/475 (2006.01) C07K 14/485 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/18 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2202533

The molecular cloning, expression, and biological characteristics of a novel receptor tyrosine kinase related to the epidermal growth factor receptor, termed HER4/p180erbB4, are described. An HER4 ligand capable of inducing cellular differentiation of breast cancer cells is also disclosed. In view of the expression of HER4 in several human cancers and in certain tissues of neuronal and muscular origin, various diagnostic and therapeutic uses of HER4- derived and HER4-related biological compositions are provided.

L'invention se rapporte au clonage moléculaire, à l'expression et aux caractéristiques biologiques d'un nouveau récepteur à activité tyrosine-kinase, apparenté au récepteur du facteur de croissance de l'épiderme, et appelé HER4/p180?erbB4¿. Un ligand de HER4 pouvant induire la différenciation cellulaire des cellules du cancer du sein est également décrit. L'HER4 étant exprimé dans plusieurs cancers humains et dans certains tissus d'origine neuronale et musculaire, différentes utilisations d'ordre thérapeutique et diagnostique de compositions biologiques apparentées à l'HER4 et dérivées d'HER4 sont décrites.

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