A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/28 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2624049
This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl- 3- methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1 ,2-b]furan-2-one (7- Hydroxy-4,1 1 (13)-eudesmadien-12,6-olide) (compound 1 ), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9- dimethyl- 3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1 ,2-b]furan-2- one (compound 1 ) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor-.alpha. (TNF- .alpha.) and interleukin (IL-1 , IL-6, IL-8) inhibitory activity of the said compositions. The invention relates to inhibition of the expression of intercellular adhesion molecule 1 (ICAM-1 ), vascular-cell adhesion molecule 1 (VCAM-1 ), and E-Selectin by the said compositions. The said compositions may optionally contain at least one anti- inflammatory agent or can be used in combination with at least one anti- inflammatory agent.
L'invention concerne une composition médicinale comprenant un extrait de fleur et de fruit de la plante Sphaeranthus indicus. L'extrait de Sphaeranthus indicus renferme un composé, 3a-hydroxy-5a,9-diméthyl-3- méthylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (7- Hydroxy-4,1 1 (13)-eudesmadien-12,6-olide) (composé 1 ) en tant que marqueur bioactif. L'invention concerne également une composition comprenant 3a-hydroxy-5a,9-diméthyl- 3-méthylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1,2-b]furan-2-one (composé 1 ) comme ingrédient actif. De plus, l'invention englobe des méthodes de fabrication desdites compositions et des méthodes d'administration à u n sujet devant être traité pour des troubles inflammatoires. L'invention porte également sur l'activité inhibitrice de ces compositions à l'égard du facteur .alpha. de nécrose des tumeurs (TNF- a) et de l'interleukine (IL-1, IL-6, IL-8). Elle concerne en outre l'inhibition par lesdits compositions de l'expression de la molécule 1 d'adhésion intercellulaire (ICAM-1 ), de la molécule 1 d'adhésion des cellules vasculaires (VCAM-1 ) et de la sélectine E. Ces compostions peuvent éventuellement contenir au moins un agent anti-inflammatoire ou peuvent être utilisées en association avec au moins un agent anti-inflammatoire.
Bal-Tembe Swati
Chauhan Vijay
Gangopadhyay Ashok Kumar
Kulkarni-Almeida Asha
Parikh Sapna Hasit
Piramal Life Sciences Limited
Riches Mckenzie & Herbert Llp
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