C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C12N 1/21 (2006.01) C12N 15/19 (2006.01) C12N 15/64 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2295317
The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of HLF activity. Also provided are diagnostic methods for detecting disorders of the regulation of cell growth and therapeutic methods for treating disorders of the regulation of cell growth.
La présente invention concerne une nouvelle protéine HLF membre de la famille des hérégulines. L'invention concerne en particulier des molécules d'acide nucléique isolées, codant ladite protéine HLF humaine. L'invention concerne également des polypeptides HLF, ainsi que des vecteurs, des cellules hôtes, et des procédés de recombinaison permettant de produire ceux-ci. Cette invention concerne enfin des procédés de criblage permettant d'identifier des agonistes et des antagonistes de l'activité HLF, des méthodes diagnostiques destinées à détecter les désordres liés à la régulation de la croissance cellulaire, et des procédés thérapeutiques visant à traiter les désordres liés à la régulation de la croissance cellulaire.
Hijazi Mai M.
King C. Richter
Ruben Steven M.
Young Paul
Georgetown University
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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