C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C12N 5/10 (2006.01) C12N 15/86 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2278151
The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-.beta.1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can include further modifications. The invention also provides nucleic acid molecules encoding heregulin variants and related vectors, host cells, pharmaceutical com-positions, and methods.
La présente invention concerne des variants d'héréguline capables de lier un récepteur ErbB. L'invention concerne également des variants d'hérégulines humaines et notamment des variants d'hérégulines-.beta.1 humaines présentant une affinité accrue vis-à-vis des récépteurs ErbB-3 et ErbB-4. Ces variants comprennent au moins une substitution d'acides aminés et peuvent présenter d'autres modifications. L'invention concerne aussi des molécules d'acides nucléiques codant des variants d'héréguline et des vecteurs associés, des cellules hôtes, des compositions pharmaceutiques et des procédés.
Ballinger Marcus D.
Fairbrother Wayne J.
Jones Jennifer T.
Sliwkowski Mark X.
Wells James A.
Battison Williams Dupuis
Genentech Inc.
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