Heregulin variants

C - Chemistry – Metallurgy – 12 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C12N 5/10 (2006.01) C12N 15/86 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2278151

The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-.beta.1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can include further modifications. The invention also provides nucleic acid molecules encoding heregulin variants and related vectors, host cells, pharmaceutical com-positions, and methods.

La présente invention concerne des variants d'héréguline capables de lier un récepteur ErbB. L'invention concerne également des variants d'hérégulines humaines et notamment des variants d'hérégulines-.beta.1 humaines présentant une affinité accrue vis-à-vis des récépteurs ErbB-3 et ErbB-4. Ces variants comprennent au moins une substitution d'acides aminés et peuvent présenter d'autres modifications. L'invention concerne aussi des molécules d'acides nucléiques codant des variants d'héréguline et des vecteurs associés, des cellules hôtes, des compositions pharmaceutiques et des procédés.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Heregulin variants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heregulin variants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heregulin variants will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1775036

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.