Heregulins (hrgs) binding proteins of p185erb2

Details Heregulins (hrgs) binding proteins of p185erb2 Heregulins (hrgs) binding proteins of p185erb2

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 1/21 (2006.01) C12N 5/02 (2006.01) C12N 5/10 (2006.01) C12P 19/34 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2108473

A novel polypeptide with binding affinity for the p185HER2 receptor, designated heregulin-.alpha., has been identified and pu-rified from cultured human cells. DNA sequences encoding additional heregulin polypeptides, designated heregulin-.alpha., heregu-lin-.beta.1, heregulin-.beta.2, heregulin-.beta.2-like, and heregulin-.beta.3, have been isolated, sequenced and expressed. Provided herein are nuc-leic acid sequences encoding the amino acid sequences of heregulins useful in the production of heregulins by recombinant means. Further provided are the amino acid sequences of heregulins and purification methods therefor. Heregulins and their an-tibodies are useful as therapeutic agents and in diagnostic methods.

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