C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) G01N 33/48 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2366124
Provided are complexes of polypeptides which include an HPS polypeptide and an HPS-interacting polypeptides (HPSIP). The HPSIP polypeptides include 14-3-3 protein, Hrs, atrophin-1, DGS-I, nuclear factor NF90, HPIP1 and human HN1 homolog protein. Also disclosed are nucleic acids encoding the HPIP1 and human HN1 homolog protein, or derivatives, fragments and analogs thereof. Methods of screening the complexes or proteins for efficacy in treating and/or preventing certain diseases and disorders, particulary atopic diseases, autoimmune diseases, neurodegenerative disease, cancer, pigmentation disorders, platelet dysfunction and viral diseases, are also disclosed.
L'invention concerne des complexes polypeptidiques qui comprennent un polypeptide HPS et des polypeptides interagissant avec le polypeptide HPS (HPSIP). Ces polypeptides HPSIP comprennent les protéine 14-3-3, Hrs, atrophine-1,DGS-I, le facteur nucléaire NF90, des protéines homologues HPIP1 et des protéines humaines HN1. L'invention concerne aussi des acides nucléiques codant pour la protéine homologue HPIP1 et la protéine humaine HN1, ou pour leurs dérivés, leur fragments et leurs analogues. Enfin, l'invention concerne des méthodes de recherche des complexes et des protéines permettant de traiter et/ou de prévenir efficacement certaines maladies et certains troubles, notamment des maladies atopiques, auto-immunes, neurodégénératives, des troubles de la pigmentation malins, des thrombopaties et des maladies virales.
Nandabalan Krishnan
Yang Meijia
Curagen Corporation
Goudreau Gage Dubuc
LandOfFree
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