Herpes subunit vaccine

A - Human Necessities – 61 – K

Patent

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A61K 39/12 (2006.01) A61K 39/245 (2006.01)

Patent

CA 1114294

HERPES SUBUNIT VACCINE ABSTRACT OF THE DISCLOSURE Herpes virus subunit antigens suitable for vaccine use are prepared by (1) treating virus-infected cells with a surfactant and varying concentrations of salt to extract and solubilize viral-directed glycoproteins, (2) fractionating the solubilized material by chromatographic procedures to enrich the viral-directed glycoproteins and to remove unwanted proteins and nucleic acids, and (3) optionally treating the subunit antigens with deoxyribonuclease and formaldehyde to assure safety.

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