C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/37, 195/1.10
C12P 21/00 (2006.01) C07K 14/035 (2006.01) C07K 16/08 (2006.01) C12N 5/00 (2006.01)
Patent
CA 1254161
ABSTRACT HERPES VIRUS SPECIFIC IMMUNOLOGICAL MATERIALS AND METHODS Disclosed are antibody substances displaying unique, multi-specific immunoreactivities with respect to glycoprotein D of Herpes Simplex Virus types 1 and 2 (HSV gD-1 and gD-2) and structurally related compounds. Illustratively, an IgG Type 2 monoclonal antibody material produced by mouse-mouse hybridoma cell line A.T.C.C. No HB8606 is capable of in vitro neutraliza- tion of HSV-1 and HSV-2 infectivity and of specific immunological reactivity and reversible immunobinding with naturally-occurring and recombinant gD-l and gD-2 in both native and denatured conformations as well as with proteinaceous materials (produced, e.g., by pro- teolytic digestion of naturally-occurring materials, by recombinant methods, or by polymerization of amino acids) which comprise a primary structural conformation substantially duplicating part or all of that which is predicted to be extant at residues 266 through 287 of gD-1 and gD-2 [i.e., PELA(or V)PEDPEDSALLEDPV(or A)GTVA(or S)]. Disclosed also are novel procedures for detection, quantification and isolation by affinity pur- ification of gD-1, gD-2 and structurally related com- pounds.
489291
Cohen Gary H.
Eisenberg Roselyn J.
Smart & Biggar
University Patents Inc.
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