Herpes virus strains

Details Herpes virus strains Herpes virus strains

C - Chemistry, Metallurgy

12

N

C12N 15/869 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2398335

The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a functional ICP47 encoding gene.

L'invention concerne un virus herpétique présentant des propriétés oncolytiques améliorées qui contient un gène codant pour une cytokine immunomodulatrice et qui est privé d'un gène fonctionnel ICP34.5 et d'un gène fonctionnel codant ICP47.

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