Herpesvirus particles and vaccine

Details Herpesvirus particles and vaccine Herpesvirus particles and vaccine

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/21 (2006.01) A61K 39/245 (2006.01) C07K 14/035 (2006.01) C12N 15/49 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2068066

In addition to virions, herpesvirus-infected cells produce non-infectious particles, termed L-particles, which consist of tegument surrounded by envelope but lack the nucleocapsid. L-particles of a herpesvirus can be prepared substantially free of infectious virions, e.g. by allowing an appropriate temperature-sensitive mutant to replicate at its non-permissive temperature, and such L-particles are useful as a component of a vaccine against the herpesvirus. They can also be prepared to contain a foreign protein or peptide, by use of a recombinant herpesvirus.

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