Herpesvirus pre-(viral dna replication) enveloped particles

Details Herpesvirus pre-(viral dna replication) enveloped particles Herpesvirus pre-(viral dna replication) enveloped particles

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/245 (2006.01) C07K 14/03 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2180346

A virus particle preparation, substantially free of virions, based on particles of a herpesvirus, especially HSV-1, which are virus- related, non-infectious particles of a herpesvirus especially an .alpha.-herpesvirus and most especially Herpes Simplex Virus 1 or 2, lacking a capsid and viral DNA, characterized in that they are pre-(viral DNA replication) particles (PREPS) lacking or containing only trace amounts of at least one of those true late proteins which are normally produced only after replication of viral DNA. They can be prepared by infecting host cells with a herpesvirus so as to prevent replication of viral DNA, but allowing the synthesis of viral proteins and particle formation and recovering a substantially virion-free PREPS.

Préparation de particules de virus, sensiblement exempte de virions, à base de particules d'un virus de l'herpès, particulièrement HSV-1, qui sont des particules apparentées au virus et non infectieuses d'un virus de l'herpès, particulièrement un .alpha.-virus de l'herpès et, plus particulièrement, le virus d'Herpès Simplex 1 ou 2, manquant d'une capside et d'ADN viral, caractérisées par le fait qu'elles sont des particules de pré-réplication d'ADN viral (PREPS) exemptes ou ne contenant que des quantités infinitésimales d'au moins une des protéines retard qui ne sont normalement produites qu'après réplication de l'ADN viral. On peut les préparer par infection de cellules hôtes avec un virus de l'herpès, afin d'empêcher la réplication de l'ADN viral, tout en permettant la synthèse de protéines virales et la formation des particules. On récupère ainsi des PREPS sensiblement exemptes de virions.

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