Herpesvirus recombinant poxvirus vaccine

C - Chemistry – Metallurgy – 12 – N

Patent

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167/130, 195/1.2

C12N 7/01 (2006.01) A61K 39/245 (2006.01) A61K 39/275 (2006.01) A61K 39/295 (2006.01) C07K 14/03 (2006.01) C07K 14/035 (2006.01) C07K 14/045 (2006.01) C07K 14/05 (2006.01) C12N 15/863 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2014465

What is described is a recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, containing foreign DNA from herpesvirus. In one embodiment, the foreign DNA is expressed in a host by the production of a herpesvirus glycoprotein. In another embodiment, the foreign DNA is expressed in a host by the production of at least two, particularly two or three, herpesvirus glycoproteins. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine. By the present invention, the barrier of maternal immunity in a newborn offspring can be overcome or avoided.

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