C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/869 (2006.01) A61K 48/00 (2006.01) C07K 14/03 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2264956
The invention relates to a means to a herpesvirus saimiri that has been genetically modified by mutating and/or deleting specific essential and non- essential genes. The essential genes are required in replication of viral genes and are needed for viral proliferation. The non-essential genes can represent sites for the insertion of heterologous genetic material, namely therapeutic genes.
La présente invention a pour objet un moyen de traitement du virus de l'herpès du singe-écureuil (Saïmiri) modifié génétiquement par mutation et/ou suppression de gènes essentiels et non essentiels spécifiques. Les gènes essentiels sont nécessaires dans la réplication des gènes viraux et la prolifération virale. Les gènes non essentiels peuvent représenter des sites d'insertion de matériel génétique hétérologue, à savoir des gènes thérapeutiques.
Markham Alexander Fred
Meredith David Mark
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The University Of Leeds
University Of Leeds
LandOfFree
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