Herpesvirus vectors and their uses

Details Herpesvirus vectors and their uses Herpesvirus vectors and their uses

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/535 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2234877

A process of treating a human or non-human animal cell to introduce heterologous genetic material into said cell and express said material in said cell, comprises (a) providing a recombinant herpesviral vector which is an attenuated or replication-defective and non-transforming mutant herpesvirus, and which carries heterologous genetic material, and (b) transducing human or non-human animal cells selected from: haematopoietic cells, malignant cells related to blood cells, and malignant or non-malignant CD34+ cells; by contacting said cells with said virus vector to transduce said cells and express said genetic material. Among applications of the technique is modification of haematopoietic cells by transfer of genes, e.g. to generate tumour immunogens from malignant cells.

Un procédé de traitement d'une cellule humaine ou animale, visant à introduire un matériel génétique hétérologue dans ladite cellule et à exprimer ledit matériel dans ladite cellule, consiste à: a) produire un vecteur du virus herpétique recombiné, lequel est un virus herpétique mutant non transformant atténué ou à déficience de réplication, et porteur d'un matériel génétique hétérologue, et b) transduire des cellules humaines ou animales, sélectionnées à partir de: cellules hématopoïétiques, cellules malignes associées à des cellules sanguines et cellules CD34+ malignes ou non malignes; par mise en contact desdites cellules avec ledit vecteur du virus afin de transduire lesdites cellules et d'exprimer ledit matériel génétique. Parmi les applications de cette technique, on peut citer la modification des cellules hématopoïétiques par transfert de gènes, en vue, par exemple, de générer des immunogènes de tumeur à partir de cellules malignes.

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