Hesperidin and hesperetin as inhibitor of acyl...

A - Human Necessities – 61 – K

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A61K 31/35 (2006.01) A23L 1/03 (2006.01) A23L 1/30 (2006.01) A23L 2/52 (2006.01) A23L 2/56 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2307890

The present invention relates to uses of hesperidin or hesperetin for inhibiting the activity of acyl CoA-cholesterol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal.

L'invention concerne des utilisations d'hespéridine ou d'hespérétine afin d'inhiber l'activité d'acyle CoA-cholestérol-o-acyltransférase, d'inhiber l'accumulation du complexe constitué par des macrophages et des lipides sur l'endothélium artériel et d'exercer une action prophylactique ou thérapeutique sur des maladies hépatiques chez le mammifère.

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