Hesperitin pro-forms with enhanced bioavailability

Details Hesperitin pro-forms with enhanced bioavailability Hesperitin pro-forms with enhanced bioavailability

C - Chemistry, Metallurgy

07

F

C07F 9/06 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/35 (2006.01) A61K 31/66 (2006.01) C07D 311/04 (2006.01) C07D 311/32 (2006.01)

Patent

CA 2358967

A hesperitin pro-form is provided. The invention provides both a hydrophilic and lipophilic hesperetin pro-form. A pharmaceutical composition is provided which is suitable for topical or oral administration in an individual, the composition comprising a hydrophilic hesperetin pro-form and a pharmaceutically acceptable carrier. A pharmaceutical composition is also provided which is suitable for topical or oral administration in an individual, the composition including a lipophilic hesperetin pro-form and a pharmaceutically acceptable carrier. A method is provided for treating a subject having or at risk of having a cell proliferative disorder, including administering to the subject a therapeutically effective amount of a hesperetin pro-form.

Cette invention concerne une proforme d'hespéritine, ainsi qu'une proforme d'hespérétine hydrophile et lipophile. Cette invention concerne également une composition pharmaceutique qui peut être administrée à un individu par voie orale ou topique, et qui comprend une proforme d'hespérétine hydrophile ainsi qu'un excipient acceptable sur le plan pharmaceutique. Cette invention aussi une composition pharmaceutique qui peut être administrée à un individu par voie orale ou topique, et qui comprend une proforme d'hespérétine lipophile ainsi qu'un excipient acceptable sur le plan pharmaceutique. Cette invention concerne également un procédé permettant de traiter un sujet qui souffre ou risque de souffrir de troubles de prolifération cellulaire, et qui consiste à administrer audit sujet une quantité efficace sur le plan thérapeutique d'une proforme d'hespérétine.

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