Hetereoaryl nitrile derivatives

Details Hetereoaryl nitrile derivatives Hetereoaryl nitrile derivatives

C - Chemistry, Metallurgy

07

D

C07D 473/00 (2006.01) C07D 239/42 (2006.01) C07D 239/94 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/06 (2006.01) C07D 473/34 (2006.01)

Patent

CA 2494931

The invention provides compounds of Formula (I) or a pharmaceutically acceptable salt or ester thereof wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in which cathepsin K is implicated, e.g. various disorders including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors.

L'invention concerne des composés de formule (I) ou un sel pharmaceutiquement acceptable ou un ester de ceux-ci. Dans cette formule, les symboles représentent les éléments définis dans la définition. Les composés de l'invention sont des inhibiteurs de la cathepsine K et sont pharmaceutiquement utiles pour le traitement de maladies et de troubles médicaux dans lesquels la cathepsine K est impliquée, par exemple, des troubles variés comprenant des inflammations, l'arthrite rhumatismale, l'ostéoarthrose, l'ostéoporose et les tumeurs.

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