(hetero) 4-arylmethoxy phenyl diazole derivatives, method...

Details (hetero) 4-arylmethoxy phenyl diazole derivatives, method... (hetero) 4-arylmethoxy phenyl diazole derivatives, method...

C - Chemistry, Metallurgy

07

D

C07D 257/04 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) C07C 243/38 (2006.01) C07C 255/66 (2006.01) C07D 271/113 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2073064

Title: "Derivatives of 4-(hereto)arylmethyloxy phenyl diazole, a method of preparing them and use thereof in therapy" (Inventors: Jean-Jacques KOENIG, Luc LEBRETON and Maryse MASSON) Applicant : DELALANDE S.A. (soci?t? anonmye) A B S T R A C T Derivatives having the formula: Image (I) in which R1 = C1-C4 alkyl and Ar is an aryl or heteroaryl group chosen from among the following: (i) Image where R2 represents a hydrogen atom one or two halogen atoms, a CN, NO2 or CF3 group, one, two or three C1-C4 alkyl or C1-C4 alkoxy groups or an amino group substituted by two C1-C4 alkyl groups, in which case the -W-V- chain represents -N = N- or Image and n = 2-6; (ii) pyridyl, in which case the -W-V- chain represents -N=N- and n = 1-6, 21 and acid addition salts of those derivatives (I) which are salt-forming. These derivatives are of use in therapy as agents for inhibiting type B monoamine oxydase.

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