C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/08 (2006.01) A61K 31/501 (2006.01) A61P 3/04 (2006.01)
Patent
CA 2626747
The present invention relates to (hetero)aryl compounds of general formula (I) wherein the groups and radicals A, B, Q, W, X, Y, Z, R1, R2, R4a, R4b, R5a, R5b, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to 10 the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.
La présente invention concerne des composés hétéroaryliques de formule générale (I), les groupements et radicaux A, B, Q, W, X, Y, Z, R1, R2, R4a, R4b, R5a, R5b ayant les significations données dans la revendication 1. En outre, la présente invention concerne des préparations pharmaceutiques contenant au moins un composé selon l'invention. Grâce à leur activité antagoniste du récepteur MCH, les préparations pharmaceutiques selon l'invention sont adaptées au traitement de troubles métaboliques et/ou de troubles de l'alimentation, en particulier l'obésité, la boulimie, l'anorexie, l'hyperphagie et le diabète.
Heckel Armin
Kley Joerg
Lehmann-Lintz Thorsten
Lotz Ralf R. H.
Lustenberger Philipp
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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