C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/81 (2006.01) A61K 31/455 (2006.01) A61K 31/47 (2006.01) A61K 31/4995 (2006.01) C07C 233/78 (2006.01) C07D 213/82 (2006.01) C07D 215/46 (2006.01) C07D 231/14 (2006.01) C07D 233/78 (2006.01) C07D 233/90 (2006.01) C07D 241/24 (2006.01) C07D 249/10 (2006.01) C07D 261/18 (2006.01) C07D 311/68 (2006.01) C07D 333/38 (2006.01) C07D 335/06 (2006.01)
Patent
CA 2523232
The present invention relates to compounds of formula (I) useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are also useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
L'invention concerne des composés de formule (I), utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies semblables. Ces composés comportent des inhibiteurs de l'enzyme bêta sécrétase utilisés dans le traitement de la maladie d'Alzheimer et d'autres maladies se caractérisant par le dépôt d'un peptide A-bêta chez un mammifère. Ces composés sont également utilisés dans des compositions pharmaceutiques ainsi que dans des procédés de traitement visant à réduire la formation du peptide A-bêta.
Aquino Jose
Hom Roy
John Varghese
Pulley Shon
Tenbrink Ruth
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company Llc
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