Hetero biaryl derivatives as matrix metalloproteinase...

Details Hetero biaryl derivatives as matrix metalloproteinase... Hetero biaryl derivatives as matrix metalloproteinase...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/41 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/4427 (2006.01) A61K 31/4439 (2006.01) A61K 31/5377 (2006.01) A61K 31/549 (2006.01) A61P 29/00 (2006.01) C07D 257/04 (2006.01) C07D 271/10 (2006.01) C07D 271/107 (2006.01) C07D 285/12 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/10 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/04 (2006.01) C07

Patent

CA 2494067

This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein Rl, Q, S, T, U, V, and R2 are as defined in the specification. The invention also provides pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, as defined in the specification, together with a' pharmaceutically acceptable carrier, diluent, or excipient. The invention also provides methods of inhibiting an MMP-13 enzyme in an animal, comprising administering to the animal a compound of Formula I, or a pharmaceutically acceptable salt thereof. The invention also provides methods of treating a disease mediated by an MMP- 13 enzyme in a patient, comprising administering to the patient a' compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides methods of treating diseases such as heart disease, multiple sclerosis, osteo- and rheumatoid arthritis, arthritis other than osteo- or rheumatoid arthritis, cardiac insufficiency,,inflammatory bowel, disease, heart failure, age-related macular degeneration, chronic obstructive pulmonary disease, asthma, periodontal diseases, psoriasis, atherosclerosis, and osteoporosis in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically, acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides combinations, comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, together with another pharmaceutically active, component as described in the specification.

L'invention porte: sur des composés de formule (I) dans laquelle R?l¿, Q, S, T, U, V, et R?2¿ sont tels que définis dans la spécification ou leurs sels pharmacocompatibles, et sur des préparations pharmaceutiques comportant un composé de formule (I), ou ses sels pharmacocompatibles, associés à un support, à un diluant ou à un excipient; sur des procédés d'inhibition chez l'animal de l'enzyme MMP-13 par administration d'un composé de formule (I), ou ses sels pharmacocompatibles; sur des méthodes de traitement de maladies médiées par l'enzyme MMP-13 par administration à un patient d'un composé de formule (I), ou ses sels pharmacocompatibles soit seuls, soit dans une préparation pharmaceutique; sur des méthodes de traitement de maladies telles que des troubles cardiaques, la sclérose en plaques, l'arthrite ostéo et rhumatoïde, les autres arthrites, l'insuffisance cardiaque, les affections abdominales inflammatoires, la dégénérescence maculaire due à l'âge, la BPCO, l'asthme, la paradontopathie, le psoriasis, l'athérosclérose, et l'ostéoporose par administration à un patient d'un composé de formule (I), ou ses sels pharmacocompatibles soit seuls, soit dans une préparation pharmaceutique. L'invention porte également sur des combinaisons contenant le composé de formule (I) et ses sels pharmacocompatibles associés à un autre composant à efficacité pharmaceutique tel que décrit dans la spécification

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