Hetero-bridge substituted 8-arylquinoline pde4 inhibitors

Details Hetero-bridge substituted 8-arylquinoline pde4 inhibitors Hetero-bridge substituted 8-arylquinoline pde4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 215/04 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61P 11/00 (2006.01) A61P 25/00 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2479069

8-arylquinolines wherein the aryl group at the 8-position contains a meta one or two atom bridge to a phenyl, 5 or 6 member heteroaryl or fused bicyclic heteroaryl group, and wherein at least one of the bridge atoms is not carbon, are PDE4 inhibitors.

Cette invention concerne des 8-arylquinoléines dans lesquelles le groupe aryle en position 8 contient un pont de un ou deux atomes en méta à un phényl, un hétéroaryle à 5 ou 6 chaînons ou un groupe hétéroaryle bicyclique fusionné, au moins un des atomes du pont n'étant pas carbone, lesquelles 8-arylquinoléines sont des inhibiteurs de PDE-4.

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