Hetero-bycyclic antiviral compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2641389

Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) wherein R1-R3 R6c and X1 are as defined herein are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV-1) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treating diseases mediated by the CCR5 receptor.

La présente invention concerne des antagonistes du récepteur de chimiokine, en particulier des composés d'octane 3,7-diazabicyclo[3.3.0] selon la formule (I) où R1-R3 R6c et X1sont tels que définis ici ; ce sont des antagonistes des récepteurs de chimiokine CCR5 utiles pour le traitement ou la prévention d'une infection par virus d'immunodéficience humaine (VIH) ou pour le traitement du SIDA ou du para-sida (ARC). L'invention fournit en outre des procédés de traitement de maladies qui sont soulagées par les antagonistes CCR5. L'invention comprend des compositions pharmaceutiques et des procédés d'utilisation des composants pour le traitement de maladies facilitées par le récepteur CCR5.

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