Hetero-imino-prostacyclins

Details Hetero-imino-prostacyclins Hetero-imino-prostacyclins

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 209/94 (2006.01) C07D 209/52 (2006.01) C07D 307/935 (2006.01) C07D 309/12 (2006.01)

Patent

CA 1198106

Abstract: Hetero-imino-prostacyclins The present invention relates to new analogs of PGI2 of the general formula I Image which have a more specific action and/or a longer period of action than PGI2 and in which: X is an oxygen or sulfur atom or an NH group, Y is a straight-chain or branched alkylene radical having up to eight carbon atoms, a straight-chain or branched unsaturated aliphatic radical having three to eight carbon atoms, a cycloaliphatic radical having three to six carbon atoms or a phenylene radical, Z is a radical of tne formula -CO2R1, -CH2OH or CH2N(R2)2, wherein R1 is hydrogen, a straight-chain or branched alkyl radlcail having up to 8 carbon atoms, a straight-chain or branched unsaturated aliphatic hydrocarbon radical having three to six carbon atoms, a cycloaliphatic hydrocarbon radical having three to seven carbon atoms, an araliphatic hydro- carbon radical having seven to nine carbon atoms or a physiologically acceptable metal ion, NH4 ion or an

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