C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4192 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 3/06 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2735794
Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardio-vascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
L'invention concerne des composés hétéroaromatiques de formule structurelle I qui sont des inhibiteurs sélectifs de la stéaroyle-coenzyme A delta-9 désaturase (SCD1) par rapport à d'autres stéaroyle-coenzyme A désaturases connues. Les composés selon l'invention sont utiles dans la prévention et le traitement d'affections liées à une synthèse et un métabolisme lipidiques anormaux, notamment les maladies cardiovasculaires, telles que l'athérosclérose, l'obésité, le diabète, les maladies neurologiques, le syndrome métabolique, l'insulinorésistance et la stéatose hépatique.
Leclerc Jean-Philippe
Li Chun Sing
Ramtohul Yeeman K.
Merck Frosst Canada Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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