C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/501 (2006.01) A61P 3/00 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2632936
Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl- coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; fatty liver disease and cancer.
Les composés hétéroaromatiques de formule structurelle (I) sont des inhibiteurs de la stéaroyl-coenzyme A delta-9 désaturase (SCD1) sélectifs, par rapport à d'autres stéaroyl-coenzyme A désaturases connues. Les composés selon la présente invention peuvent être employés dans le traitement prophylactique et thérapeutique d'états pathologiques liés à une synthèse et un métabolisme lipidiques anormaux, y compris une maladie cardio-vasculaire telle que l'athérosclérose ; des troubles lipidiques ; l'obésité ; le diabète ; une maladie neurologique ; le syndrome métabolique ; l'insulinorésistance ; la stéatose hépatique et le cancer.
Deschenes Denis
Fortin Rejean
Li Chun Sing
Oballa Renata
Ramtohul Yeeman K.
Merck Frosst Canada Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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