Heteroaromatic compounds as inhibitors of stearoyl-coenzyme...

C - Chemistry – Metallurgy – 07 – D

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C07D 417/14 (2006.01) A61K 31/501 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2615045

Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl- coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and fatty liver disease.

La présente invention concerne des composés hétéroaromatiques de formule développée (I) qui sont des inhibiteurs sélectifs d'une coenzyme stéaroyle A delta-9 désaturase (SCD1) par rapport à d'autres coenzymes stéaroyle A désaturases connues. Les composés selon cette invention sont utilisés pour prévenir et traiter des pathologies liées à une synthèse et à un métabolisme anormaux des lipides, y compris des maladies cardio-vasculaires, l'athérosclérose, des troubles lipidiques, l'obésité, le diabète, des maladies neurologiques, le syndrome métabolique, une résistance à l'insuline et une stéatose hépatique.

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