C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/428 (2006.01) A61K 31/437 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2738348
Heteroaromatic compounds of structural formula (I) are inhibitors of stearoyl- coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis.
L'invention porte sur des composés hétéroaromatiques de formule structurale (I) qui sont des inhibiteurs de la stéaroyl-coenzyme A delta-9 désaturase (SCD). Les composés de la présente invention sont utiles pour la prévention et le traitement d'états liés à une synthèse et à un métabolisme anormaux des lipides, comprenant des maladies cardiovasculaires, telles que l'athérosclérose ; l'obésité ; le diabète de type 2 ; une résistance à l'insuline ; une hyperglycémie ; le syndrome métabolique ; des maladies neurologiques ; un cancer ; et une stéatose hépatique.
Leclerc Jean-Philippe
Li Chun-Sing
Ramtohul Yeeman K.
Merck Frosst Canada Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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