Heteroaromatic compounds for use as hif inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 413/04 (2006.01) A61K 31/4245 (2006.01) A61K 31/435 (2006.01) C07D 413/14 (2006.01) A61P 3/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2743424

The present application relates to novel substituted aryl compounds, processes for their preparation, their use for treatment and/or prevention of diseases and their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.

La présente invention concerne de nouveaux composés aryles substitués, un procédé permettant de les préparer, leur utilisation pour le traitement et/ou la prévention de maladies ainsi que leur utilisation pour la fabrication de médicaments pour le traitement et/ou la prévention de maladies, en particulier pour le traitement et/ou la prévention de maladies hyperprolifératives et angiogèniques, ainsi que des maladies qui se produisent par une adaptation métabolique à des états hypoxiques. De tels traitements peuvent avoir lieu en tant que monothérapie ou également en combinaison avec d'autres médicaments ou autres mesures thérapeutiques.

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