C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) C07D 275/04 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01)
Patent
CA 2155758
The present invention relates to a group of piperazine and piperidine derivatives of formula (I), wherein Y is a heteroaryl group optionally sub- stituted by one or more halogen, nitro, C1-6alkyl, C1-6alkoxy, aryloxy, arylC1-6alkylenoxy, hydroxy, S(O)nR2 or S(O)nN(R2)2 where n is 0, 1 or 2, CN, CON(R2)2, COR2, CO2R2, CO-aryl, azido, - N(R2)2, -NR2N(R2a)2, -NR2N = C(R2a)2, -NR2(C = O)CH(N(R2a)R2b, -NR2(C = O)R2a, NR2CO2R2a, C1-6alkoxycarbonylamino or PhN = N; with the pro- viso that Y does not include benzisothiazolyls or ben- zisozazlyis, V is -O- or S; Z is C1-8alkylene optionally interrupted by -O- or -S(O)n where n is 0, 1 or 2, C2- 8alkenylene or C2-8alkynylene; X is N, CR3 or COR3-; A is CR4 or N; B is oxygen, NR5 or S(O)n, where n is 0, 1 or 2; and R1 is hydrogen or one or more halogen, hydroxy, nitro, CN, NR62, C1-6alkoxy, aryloxy, arylC1-6alkylenoxy, or COR6, R, R2, R2a, R2b, R3, R4, R5 and R6, are each hydrogen or C1-6alkyl; or a salt, solvate, N-oxide or physiologically functional derivative thereof,to processes for their preparation, to pharmaceutical compositions containing them and to their use in therapy, in particular in the treatment of psychotic disorders.
Navas Frank III
Norman Mark Henry
Swabey Ogilvy Renault
The Wellcome Foundation Limited
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