Heteroaromatic glucokinase activators

Details Heteroaromatic glucokinase activators Heteroaromatic glucokinase activators

C - Chemistry, Metallurgy

07

D

C07D 277/46 (2006.01) A61K 31/426 (2006.01) A61P 3/10 (2006.01) C07D 277/54 (2006.01)

Patent

CA 2590720

The present invention describes 2,3-di-substituted N-heteroaromatic propionamides, of Formula (I) wherein the substitution at the 3-position is an optionally substituted phenyl ring and the substitution at the 2-position is an alkyl or cycloalkyl group; pharmaceutical compositions comprising the same; and, methods of using the same. The propionamides are glucokinase activators for the treatment of type II diabetes.

La présente invention décrit des propionamides N-hétéroaromatiques 2,3-disubstitués de Formule (I), dans lesquels le substituant en position 3 est un cycle phénylique éventuellement substitué et le substituant en position 2 est un groupement alkyle ou cycloalkyle. La présente invention décrit également des préparations pharmaceutiques comprenant lesdits composés, ainsi que des méthodes d~emploi desdits composés. Les propionamides sont des agents activants de glucokinase employés dans le traitement de diabètes de type II.

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