Heteroaryl acetylenic sulfonamide and phosphinic acid amide...

Details Heteroaryl acetylenic sulfonamide and phosphinic acid amide... Heteroaryl acetylenic sulfonamide and phosphinic acid amide...

C - Chemistry, Metallurgy

07

D

C07D 213/78 (2006.01) A61K 31/44 (2006.01) A61P 19/02 (2006.01) A61P 31/18 (2006.01) C07C 309/42 (2006.01) C07C 309/87 (2006.01) C07D 231/42 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2356481

Compounds of formula (I) are useful in treating disease conditions mediated by TNF-.alpha. such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

Cette invention concerne des composés correspondant à la formule (I) qui sont utiles dans le traitement d'états maladifs induits par le facteur de nécrose tumorale .alpha., tels que l'arthrite rhumatoïde, l'arthrose, la septicémie, le SIDA, la colite ulcéreuse, la sclérose multiple, la maladie de Crohn et la perte de cartilage dégénérative.

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