Heteroaryl alkyl piperazine derivatives as fatty acid...

C - Chemistry – Metallurgy – 07 – D

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C07D 417/12 (2006.01) A61K 31/496 (2006.01) A61P 21/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2426535

Novel compounds of the general formula (I): and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.

Nouveaux composés représentés par la formule (I) et leurs sels d'apport acide acceptables sur le plan pharmaceutique, ces composés présentant une utilité thérapeutique pour protéger les muscles du squelette contre la détérioration provenant d'un traumatisme ou protéger ces muscles à la suite de maladies musculaires ou systémiques, telles que la claudication intermittente, pour traiter des états de choc, préserver des tissus et des organes donneurs utilisés dans des transplants, dans le traitement de maladies cardio-vasculaires, y compris des arythmies atriales et ventriculaires, pour traiter l'angine de poitrine inversée, l'angine stable, l'angine survenant à l'effort, l'insuffisance cardiaque et l'infarctus du myocarde.

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