Heteroaryl amide analogues

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2682925

Heteroaryl amide analogues are provided, of Formula (I), wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

L'invention concerne des analogues d'hétéroaryl-amides de Formula (I), dans laquelle les variables sont telles que définies dans la description. Ces composés sont des ligands qui peuvent être utilisés pour moduler une activité de récepteur spécifique in vivo ou in vitro et qui sont particulièrement utiles dans le traitement d'affections associées à une activation de récepteur pathologique chez des humains, des animaux domestiques et des animaux d'élevage. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation de ces composés dans le traitement de ces troubles, ainsi que des méthodes d'utilisation de ces ligands dans des études de localisation de récepteurs.

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